ASSESSMENT OF THYROID HORMONES AND TESTOSTERONE AMONG TRAMADOL-ABUSERS IN GAZA STRIP-PALESTINE
Keywords:opioids, TRAMADOL, thyroid function, testosterone, Gaza Strip
Introduction: Tramadol is a prescription opioid used to treat moderate pain. But among Tramadolabusers in Gaza Strip, little is known regarding Tramadol's effect on their body functions such as levels of thyroid hormones and testosterone. The aim of the study was to investigate the effect of tramadol abuse on the level of thyroid hormones and testosterone among tramadol-abusers in Gaza Strip. Methods: This study used a prospective case-control design performed on a population of Tramadol overdosed patients, aged 18 to 35 years old who were admitted to psychiatric clinics in the Gaza Strip. Questionnaires on sociodemographic and clinical data were collected from 196 males (98 cases from tramadol abusers who followed before pre-detoxification and one-month later post detoxification and an equal number of healthy individuals with matching age as control. TSH, FT4, FT3, and Testosterone levels were measured, statistically analyzed. Results: There was an association between tramadol abuser's pre-treatment and healthy subjects for thyroid parameters and testosterone. T-test showed tramadol abusers pre-detoxification were significantly increased in TSH levels than controls (P<0.001) conversely, they were significantly decreased in serum FT4, FT3, and testosterone levels than controls also paired t-test illustrated level of TSH for pre-detoxification were significantly higher than postdetoxification. Additionally, there is no significant correlation between controls and tramadol abusers' groups (pre & post-treatment) in hematological profile (P>0.05) except in red cell distribution width (RDW) that showed a positive significant correlation between controls and tramadol abusers groups in both pre & post-treatment (P=0.021). Conclusion: The study concluded that tramadol abusing have a significantly decreased level of Testosterone, FT4, and FT3 levels and a significantly high level of TSH, also we conclude that the level of testosterone, T3, and T4 in pre detoxification of tramadol abusers was significantly lower than controls and significantly lower than its results after detoxification.
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Copyright (c) 2021 Alaa Mudalala, Saleh Mwafy, Fadel Ashour, Majed Jebril
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