THE ROLE OF HYDROXYCHLOROQUINE AS MONOTHERAPY IN MANAGING EARLY UNDIFFERENTIATED ARTHRITIS: A PROSPECTIVE HOSPITAL-BASED STUDY

Ziryab Imad Taha  Mahmoud; Mustafa Mohamed Ali  Hussein; Mohammed Elmujtba Adam Essa; Sherihan Mohammed  Elkundi Osman; Mutwaly Defealla Yousif  Haron; Mohammed Altyb  Alshykh; Elnour Mohammed  Elagib; Abdelkareem Abdallah Ahmed

doi:10.37557/gjphm.v1i2.9

Authors

Ziryab Imad Taha Mahmoud Department of Clinical Medicine, Medical and Cancer Research Institute (MCRI), Nyala, Sudan
Mustafa Mohamed Ali Hussein Department of Health, Faculty of Medicine, Al Fashir University, Al Fashir, Sudan.
Mohammed Elmujtba Adam Essa Medical and Cancer Research Institute
Sherihan Mohammed Elkundi Osman Department of Molecular Medicine, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
Mutwaly Defealla Yousif Haron Department of Health, Faculty of Medicine, Al Fashir University, Al Fashir, Sudan
Mohammed Altyb Alshykh Faculty of Medicine, Alzaim Alazhari University, Khartoum, Sudan
Elnour Mohammed Elagib Department of Internal Medicine and Rheumatology, Omdurman Military Hospital, Khartoum, Sudan.
Abdelkareem Abdallah Ahmed Department of Physiology and Biochemistry, Faculty of Veterinary Science, University of Nyala, Nyala, Sudan

DOI:

https://doi.org/10.37557/gjphm.v1i2.9

Keywords:

Early undifferentiated arthritis, Middle age group, Hydroxychloroquine, Monotherapy.

Abstract

Introduction: Early undifferentiated arthritis (EUA) is a common form of arthritis comprising, joint pain, stiffness and swelling with no definitive diagnosis. Patients of EUA can progress to other forms of rheumatic arthropathies such as rheumatoid arthritis or remain in the same form or spontaneously disappear. The main focus of this study is to explore the potential effect of hydroxychloroquine (HCQ) in management of EUA as a monotherapy treatment. Methods: This is a prospective hospital-based study which was conducted in Almwada hospital in Khartoum, Sudan. The study included thirty patients of EUA. Full clinical examination and history were done by a rheumatologist, and all the related investigations were obtained, and they all received HCQ after EUA diagnosis has been established. Result: The study shows that 96% of the patients responded well to the treatment and 10% had their duration of treatment doubled to show a favorable response. We also found that female patients weremore commonly affected than male ones with higher incidence among middle aged as compared to others. After treatment with HCQ, 86.6% of the patients showed average mean decrease in erythrocyte sedimentation rate (ESR) by 44%, the other 13.4%, even though they were symptoms free after treatment they showed increased level of ESR by 30% average. Conclusion: In the present study we found out most of the EUA patients are well responded to the HCQ treatment, and most of them respond from the first course of treatment, the study also shows higher incidence among female in compared to male.